Outcome after steroid withdrawal in renal transplant patients receiving tacrolimus-based immunosuppression.
نویسندگان
چکیده
N 289 (76%) 90 (24%) Median time to withdrawal (months) 10 Uving donor 92% 8% Cadaveric donor' 75% 25% Donor age (y)' 32.9:!: 19.8 38.8: 21.4 Donors <60 y 79% 21% Donors >60 y" 53% 47% Tacrolimuslprednisone 77% 22% Tacrolimuslprednisonelazathioprine 76% 23% Delayed graft function ... no 81% 19% yes 67% 33% Acute rejection .. no 87% 13% 65% 35% Patient survivalt 1 y (actual) 99% 91% 3 Y (actuarial) 98% 80% Graft survivalt 1 y (actual) 98% 77% 3 Y (actuarial) 94% 50% Rejectiont 43% 73% Serum creatinine (mgldL) 1 y" 1.6 :t 0.6 2.3: 1.5 2 ytt 1.7:0.7 2.3: 1.3 Cytomegalovirus 15% 23% Tacrolimus dose (mglkg per d) 1 yttt 0.15: 0.11 0.19:!: 0.15 2 ytttt 0.13 :t 0.08 0.18:!: 0.09
منابع مشابه
Outcome after steroid withdrawal in adult renal transplant patients receiving tacrolimus-based immunosuppression.
CORTICOSTEROIDS, in spite of their well-known side effects, have essentially always been an integral part of immunosuppressive regimens in renal transplantation. With the introduction of tacrolimus, however, steroid withdrawal has been possible in some 70% of successfully transplanted adults and children. 1-8 An important question, however, concerns the outcome after steroid withdrawal in adult...
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عنوان ژورنال:
- Transplantation proceedings
دوره 30 4 شماره
صفحات -
تاریخ انتشار 1998